Lateinischer Name: Agaricus blazei, Agaricus subrufescens, Agaricus brasiliensis

Andere Namen: ABM, almond mushroom, mushroom of the sun (englisch), Mandelpilz, Brasilianischer Mandel-Egerling (deutsch), Agaricus blazei (französisch).

Aktive Inhaltsstoffe: Polysaccharide (Beta-Glucane, Hetero-Glucane, Xylo-Glucane), Enzyme (Amylase, Trypsin, Protease, Tyrosinase), Glycoprotein (Lektin).

Der Ursprung dieses Pilzes liegt in der Stadt Piedade bei Sao Paulo in Brasilien. Das Klima dort ist ideal für die Verbreitung dieser Pilzart. Heute wird der Pilz auch andernorts unter den gleichen Bedingungen gezüchtet.

Aufgrund der verschiedenen im Agaricus gefundenen Inhaltsstoffe gibt es mehrere medizinische Anwendungen, die nachfolgend kurz zusammengefasst werden.

Anwendung von Agaricus blazei in der TCM (Traditionelle Chinesische Medizin)

Wissenschaftliche Studien

Wissenschaftliche Forschung zu Agaricus blazei – 38 verfügbare Referenzen

1. Bensky D, Clavey S, Stogër E, Gamble A. Ling Zhi. Chinese Herbal Medicine: Materia Medica. 3rd ed. Seattle: Eastland Press; 2004:933-935.
2. M. Endo, H. Beppu, H. Akiyama, K. Wakamatsu, S. Ito, Y. Kawamoto, K. Shimpo, T. Sumiya, T. Koike and T. Matsui - Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells, 2010,Biochim Biophys Acta,volume: 1800,issue: 7,pages: 669-73
3. F. M. Jumes, D. Lugarini, A. L. Pereira, A. de Oliveira, O. Christoff Ade, G. A. Linde, J. S. do Valle, N. B. Colauto and A. Acco - Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats, 2010, Can J Physiol Pharmacol,volume: 88,issue: 1,pages: 21-7
4. Y. C. Niu, J. C. Liu, X. M. Zhao, F. Q. Su and H. X. Cui - Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice, 2009,Pharmazie,volume: 64,issue: 7,pages: 472-6
5. L. Ziliotto, F. Pinheiro, L. F. Barbisan and M. A. Rodrigues - Screening for in vitro and in vivo antitumor activities of the mushroom Agaricus blazei, 2009, Nutr Cancer,volume: 61,issue: 2,pages: 245-50
6. C. F. Kim, J. J. Jiang, K. N. Leung, K. P. Fung and C. B. Lau - Inhibitory effects of Agaricus blazei extracts on human myeloid leukemia cells, 2009, J Ethnopharmacol, volume: 122,issue: 2,pages: 320-6
7. Y. C. Niu, J. C. Liu, X. M. Zhao and X. X. Wu - A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo, 2009,Oncol Rep,volume: 21,issue: 1,pages: 145-52
8. L. Gao, Y. Sun, C. Chen, Y. Xi, J. Wang and Z. Wang - Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill, 2007, Braz J Med Biol Res, volume: 40, issue: 11, pages: 1545-55
9. T. W. Oh, Y. A. Kim, W. J. Jang, J. I. Byeon, C. H. Ryu, J. O. Kim and Y. L. Ha - Semipurified fractions from the submerged-culture broth of Agaricus blazei Murill reduce blood glucose levels in streptozotocin-induced diabetic rats, 2010,J Agric Food Chem,volume: 58,issue: 7,pages: 4113-9
10. N. Y. Tang, J. S. Yang, J. P. Lin, T. C. Hsia, M. J. Fan, J. J. Lin, S. W. Weng, Y. S. Ma, H. F. Lu, J. J. Shen, J. G. Lin and J. G. Chung - Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice, 2009, In Vivo,volume: 23,issue: 5,pages: 761-6
11. E. Yuminamochi, T. Koike, K. Takeda, I. Horiuchi and K. Okumura - Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill, 2007, Immunology, volume: 121,issue: 2,pages: 197-206
12. S. Bernardshaw, G. Hetland, L. K. Ellertsen, A. M. Tryggestad and E. Johnson - An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro, 2005, Journal: Inflammation, volume: 29,issue: 4-6,pages: 147-53
13. C. Y. Jin, Y. H. Choi, D. O. Moon, C. Park, Y. M. Park, S. C. Jeong, M. S. Heo, T. H. Lee, J. D. Lee and G. Y. Kim - Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei, 2006, Oncol Rep, volume: 16, issue: 6, pages: 1349-55
14. G. Y. Kim, M. Y. Lee, H. J. Lee, D. O. Moon, C. M. Lee, C. Y. Jin, Y. H. Choi, Y. K. Jeong, K. T. Chung, J. Y. Lee, I. H. Choi and Y. M. Park - Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells, 2005, Int Immunopharmacol, volume: 5,issue: 10, pages: 1523-32
15. P. Bobek and S. Galbavy - Effect of pleuran (beta-glucan from Pleurotus ostreatus) on the antioxidant status of the organism and on dimethylhydrazine-induced precancerous lesions in rat colon, 2001, Br J Biomed Sci, volume: 58, issue: 3, pages: 164-8
16. A. Jedinak and D. Sliva - Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway, 2008, Int J Oncol, volume: 33, issue: 6, pages: 1307-13
17. H. Tong, F. Xia, K. Feng, G. Sun, X. Gao, L. Sun, R. Jiang, D. Tian and X. Sun - Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus, 2009, Bioresour Technol, volume: 100, issue: 4, pages: 1682-6
18. E. R. Wolff, E. Wisbeck, M. L. Silveira, R. M. Gern, M. S. Pinho and S. A. Furlan - Antimicrobial and antineoplasic activity of Pleurotus ostreatus, 2008, Appl Biochem Biotechnol, volume: 151, issue: 2-3, pages: 402-12
19. R. M. Gern, E. Wisbeck, J. R. Rampinelli, J. L. Ninow and S. A. Furlan - Alternative medium for production of Pleurotus ostreatus biomass and potential antitumor polysaccharides, 2008, Bioresour Technol, volume: 99, issue: 1, pages: 76-82
20. Y. H. Gu and G. Sivam - Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen-independent prostate cancer PC-3 cells, 2006, J Med Food, volume: 9, issue: 2, pages: 196-204
21. I. Sarangi, D. Ghosh, S. K. Bhutia, S. K. Mallick and T. K. Maiti - Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans, 2006, Int Immunopharmacol, volume: 6, issue: 8, pages: 1287-97
22. I. Lavi, D. Friesem, S. Geresh, Y. Hadar and B. Schwartz - An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells, 2006 , Cancer Lett, volume: 244. issue: 1, pages: 61-70
23. S. Kurashige, Y. Akuzawa and F. Endo - Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine, 1997, Immunopharmacol Immunotoxicol, volume: 19, issue: 2, pages: 175-83
24. K. Khatun, H. Mahtab, P. A. Khanam, M. A. Sayeed and K. A. Khan - Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects, 2007,Mymensingh Med J, volume:16, issue: 1, pages: 94-9
25. K. Sepcic, S. Berne, K. Rebolj, U. Batista, A. Plemenitas, M. Sentjurc and P. Macek - Ostreolysin, a pore-forming protein from the oyster mushroom, interacts specifically with membrane cholesterol-rich lipid domains, 2004,FEBS Lett, volume:575,issue: 1-3,pages: 81-5
26. S. Hossain, M. Hashimoto, E. K. Choudhury, N. Alam, S. Hussain, M. Hasan, S. K. Choudhury and I. Mahmud - Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic rats, 2003,Clin Exp Pharmacol Physiol, volume: 30, issue:7, pages: 470-5
27. P. Bobek and S. Galbavy - Hypocholesterolemic and antiatherogenic effect of oyster mushroom (Pleurotus ostreatus) in rabbits, 1999,Nahrung, volume:43, issue:5, pages: 339-42
28. P. Bobek and S. Galbavy - [The oyster mushroom (Pleurotus ostreatus) effectively prevents the development of atherosclerosis in rabbits], 1999, Ceska Slov Farm, volume:48, issue:5, pages: 226-30
29. S. H. Hu, Z. C. Liang, Y. C. Chia, J. L. Lien, K. S. Chen, M. Y. Lee and J. C. Wang - Antihyperlipidemic and antioxidant effects of extracts from Pleurotus citrinopileatus, 2006,J Agric Food Chem,volume:54,issue: 6, pages: 2103-10
30. I. Kajaba, R. Simoncic, K. Frecerova and G. Belay - Clinical studies on the hypolipidemic and antioxidant effects of selected natural substances, 2008, Bratisl Lek Listy, volume:109, issue:6, pages: 267-72
31. D. Das, S. Mondal, S. K. Roy, D. Maiti, B. Bhunia, T. K. Maiti, S. R. Sikdar and S. S. Islam - A (1-->6)-beta-glucan from a somatic hybrid of Pleurotus florida and Volvariella volvacea: isolation, characterization, and study of immunoenhancing properties, 2010, Carbohydr Res, volume: 345, issue: 7, pages: 974-8
32. Y. Sun and J. Liu - Purification, structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus, 2009, Bioresour Technol, volume: 100, issue: 2, pages: 983-6
33. J. N. Chen, Y. T. Wang and J. S. Wu - A glycoprotein extracted from golden oyster mushroom Pleurotus citrinopileatus exhibiting growth inhibitory effect against U937 leukemia cells, 2009, J Agric Food Chem, volume: 57, issue: 15, pages: 6706-11
34. K. Bauerova, E. Paulovicova, D. Mihalova, K. Svik and S. Ponist - Study of new ways of supplementary and combinatory therapy of rheumatoid arthritis with immunomodulators. Glucomannan and Imunoglukan in adjuvant arthritis, 2009, Toxicol Ind Health, volume: 25, issue: 4-5, pages: 329-35
35. S. W. Kim, H. G. Kim, B. E. Lee, H. H. Hwang, D. H. Baek and S. Y. Ko - Effects of mushroom, Pleurotus eryngii, extracts on bone metabolism, 2006, Clin Nutr, volume:25, issue:1, pages: 166-70
36. N. Dalonso, R. Souza, M. L. Silveira, A. A. Ruzza, T. M. Wagner, E. Wisbeck and S. A. Furlan - Characterization and antineoplasic effect of extracts obtained from Pleurotus sajor-caju fruiting bodies, 2010, Appl Biochem Biotechnol, volume: 160, issue: 8, pages: 2265-74
37. Karmali, K. - Agaricus blazei: New Developments in Mushroom Nutrition, 2005, Mycology News, Vol. 1, No. 10
38. Cheung, P.C.K. - The hypocholesterolemic effect of two edible mushrooms: Auricularia auricular (tree-ear) and Tremella fuciformis (white jelly leaf) in hypercholesterolemic rats, 1996, Nutrition Research, Volume 16, No. 10, pp: 1721-1725